CAREFULLY CRAFTED IN THE USA: Our recipe is formulated with natural, high quality ingredients that are corn free, soy free, wheat free, and have no artificial colors, flavors, or preservatives. VET RECOMMENDED FOR LARGE BREED DOGS: Our vet recommended dental chew is specifically formulated for large breed dogs, 12 weeks and older, with a weight of 40 pounds or more. BRUSH TWO TIMES A DAY: For best results, we recommend a tooth-brushing regimen of two Brushless chews per day. For even longer lasting effectiveness, try combining with Brushless Plaque-Zapper. HELPS FIGHT PLAQUE & TARTAR AND FRESHENS BREATH: Outside ridges abrasively clean teeth, help reduce stains, and polish teeth while toothpaste center helps fight plaque, tartar, and bacteria causing bad breath with natural ingredients such as alfalfa, cinnamon, vanilla, and clove. 4-in-1 NATURAL DOG DENTAL CHEW: Contains (1) 54oz box of Brushless Toothpaste for Large Breeds. Designed to abrasively clean teeth, mechanically help reduce plaque and tartar buildup, and freshen breath.