Creatine monohydrate maintains its recognition as being the most effective, science backed supplemental source, some fitness enthusiasts and athletes, prefer alternate creatine varieties. Creatine HCL's ability to dissolve, absorb and metabolize, makes it a recognized form as the "next-gen" of creatine sources. Creatine HCL is a highly soluble form, which improves digestive response of the creatine through that solubility. When you attach an HCL molecule to creatine, you make the creatine more acidic. This drastically increases its solubility. Creatine HCL has been shown to be about 40 times more soluble in fluid comparably to its parent, creatine monohydrate, and 60 more absorbable through the intestinal wall. This means that you can take a smaller dose of creatine HCL, and there is less chance of experiencing side effects associated, such as subcutaneous (under-the-skin) water retention.Creatine HCL has been shown to be about 40 times more soluble in fluid comparably to its parent, creatine monohydrate, and 60 more absorbable through the intestinal wall. Creatine HCL is a highly soluble form, which improves digestive response of the creatine through that solubility. Creatine HCL's ability to dissolve, absorb and metabolize, makes it a recognized form as the "next-gen" of creatine sources. Creatine hydrochloride (HCL) is made by attaching a HCL group to creatine.